Asimadoline 是一种 κ-阿片(κ-opioid)受体激动剂,对豚鼠和人重组 κ-opioid 的IC50值分别为 5.6 和 1.2 nM。它可改善糖尿病大鼠的异常性疼痛,具有外周抗炎作用,并有用于肠易激综合征的研究潜力。
产品描述
Asimadoline is a proprietary small molecule therapeutic, originally discovered by Merck KGaA of Darmstadt, Germany. Asimadoline was originally developed to treat peripheral pain such as arthritis. Asimadoline is an orally administered agent that acts as a kappa opioid receptor agonist. It has shown encouraging clinical efficacy for the treatment of IBS in a barostat study in IBS patients and has the potential for treating other gastrointestinal diseases.
Cas No.
153205-46-0
分子式
C27H30N2O2
分子量
414.54
别名
EMD-61753;阿西马朵林
储存和溶解度
DMSO:103.3 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years