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Nelonicline
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nelonicline图片
CAS NO:1026134-63-3
包装与价格:
包装价格(元)
5 mg电议
10 mg电议

产品名称
ABT-126
产品介绍

产品描述

Nelonicline is a selective agonist of neuronal nicotinic receptors.

体内活性

Nelonicline (0.03 mg/kg) treatment, has no significant effect on LIDs. The effect of Nelonicline (1.0 mg/kg) is also tested for its ability to reduce LIDs at a higher dose of L-dopa (15 mg/kg)/carbidopa (3.75 mg/kg). The higher dose of L-dopa leads to greater LID scores in vehicle-treated monkeys. Nelonicline treatment reduces LIDs by 70%, after the morning dose of L-dopa and 60% after the afternoon dose. The effect of Nelonicline is most pronounced during the latter weeks, possibly because of a greater decline with continued drug treatment. Nelonicline (0.10 mg/kg)treatment, decreases LIDs by ~40%, while the 0.30 and 1.0 mg/kg Nelonicline doses decrease LIDs up to ~60%. These data indicate that Nelonicline would be useful as an antidyskinetic drug in Parkinson's disease.

Cas No.

1026134-63-3

分子式

C17H19N3OS

分子量

313.42

别名

ABT-126

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years