O-Desmethyl gefitinib 是依赖于 CYP2D6 活性形成的，是 Gefitinib 在人血浆中的活性代谢产物。在亚细胞试验中，它抑制EGFR，IC50为 36 nM。

O-Desmethyl gefitinib inhibits EGFR (IC50: 36 nM in subcellular assays). In human plasma, O-Desmethyl gefitinib is an active metabolite of Gefitinib. The formation of O-desmethyl gefitinib is dependent on the CYP2D6 activity.

847949-49-9

C21H22ClFN4O3

432.88

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years