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NS309
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NS309图片
CAS NO:18711-16-5
包装与价格:
包装价格(元)
5 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
NS309 是选择性钙依赖性钾离子通道 SK/IK 的激活剂,在 BK 通道上没有激活作用。

产品描述

NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 μM for SK channels and 10-90 nM for IK channels). It can also activate voltage-gated Kv11.1 channels (hERG; IC50 = 1 μM), but does not, however, affect large conductance (BK/KCa1.1) channels. NS309 can modulate neuronal firing patterns by enhancing SK-mediated hyperpolarizing effects. It is 730-fold (SK channels) and 7,400-fold (IK channels) more potent than 1-EBIO and often used in conjunction with CyPPA to distinguish between SK1 and SK3 subtypes.

Cas No.

18711-16-5

分子式

C8H4Cl2N2O2

分子量

231.03

储存和溶解度

DMSO:50 mg/mL (216.41 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years