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CP-547632 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CP-547632 hydrochloride图片
CAS NO:252003-71-7
包装:100 mg
市场价:8517元

产品介绍

产品描述

CP-547632 hydrochloride is a well-tolerated and orally-bioavailable inhibitor of the VEGFR-2 and basic FGF kinases (IC50s: 11 nM and 9 nM) with antitumor efficacy.

体外活性

CP-547632 hydrochloride (1-1000 nM; 1 hours) inhibits VEGF-stimulated VEGFR-2 phosphorylation in a dose-dependent fashion (IC50: 6 nM).

体内活性

In DLD-1, Colo-205, and MDA-MB-231 xenografts, CP-547632 hydrochloride (p.o.; 6.25-100 mg/kg/day; for 10-24 days) causes a dose-dependent inhibition of growth. CP-547632 hydrochloride (oral; 50 mg/kg) yields plasma concentrations above 500 ng/ml for 12 hours.

Cas No.

252003-71-7

分子式

C20H25BrClF2N5O3S

分子量

568.86

储存和溶解度

DMSO:38.33 mg/mL (67.38 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years