MRTX0902 是一种有效且高选择性的 SOS1 抑制剂，IC50 为 46 nM，Ki 为 2 nM。

MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM.

In the MIA PaCa-2 xenograft model of mice, MRTX0902 (25 and 50 mg/kg; p.o.) shows anti-tumor effects and reduces tumor growth by 41% and 53%, respectively[1].

2654743-22-1

C22H24N6O

388.47

DMSO:10 mg/mL (25.7 mM),ultrasonic and warming and heat to 60°C
Powder: -20°C for 3 years
In solvent: -80°C for 2 years