(Z)-Guggulsterone 是印度阿育吠陀药用植物Commiphora mukul的成分,可通过引起细胞凋亡来抑制人前列腺癌细胞的生长,还可通过抑制VEGF-VEGF-R2-Akt信号传导轴来抑制血管生成。
产品描述
(Z)-Guggulsterone inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis.
体外活性
In HUVEC, Z-guggulsterone (10, 20 μM; 24 or 48 hours) induces a reduction in the level of VEGF-R2 protein [1].
体内活性
In tumor volume and wet tumor weight, Z-guggulsterone (p.o.; 1 mg; 5 times/week) causes a statistically significant reduction [1].
Cas No.
39025-23-5
分子式
C21H28O2
分子量
312.45
储存和溶解度
DMSO:10 mg/mL (32.01 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years