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Ningetinib
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ningetinib图片
CAS NO:1394820-69-9
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议

产品名称
CT053PTSA
宁格替尼
CT-053
产品介绍
Ningetinib 是口服具有活力的、小分子酪氨酸激酶抑制剂,能够抑制 c-Met (IC50:6.7 nM),VEGFR2 (IC50:1.9 nM) 和 Axl (IC50<1.0 nM)。

产品描述

Ningetinib (CT053PTSA) is an orally bioavailable tyrosine kinase inhibitor with IC50s of<1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.

体外活性

In cell-based functional assays, Ningetinib inhibits VEGF and HGF-stimulated HUVEC proliferation and microvascular angiogenesis in rat aortic rings with IC50 values of 6.3 and 8.6 nM, respectively.

体内活性

In the orthotopic U87MG human glioblastoma xenograft model, Ningetinib prolongs the median survival time and yields a significant increase in life-span value (ILS=32%) at an oral dose of 20 mg/kg/day (dosed 21 days) versus the vehicle-treated group. When single dosed orally (3 mg/kg) to U87MG tumor-bearing nude mice, Ningetinib potently inhibits the phosphorylation of c-Met and its downstream signaling kinases AKT and ERK1/2 for up to 6 hours in tumor tissues.

Cas No.

1394820-69-9

分子式

C31H29FN4O5

分子量

556.58

别名

CT053PTSA;宁格替尼;CT-053

储存和溶解度

DMSO:15 mg/mL (26.95 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years