HIF-2α-IN-3 is an allosteric inhibitor of HIF-2α (IC50: 0.4 μM; KD: 1.1 μM) with anticancer activity.

HIF-2α-IN-3 ?inhibit HIF-2α-ARNT heterodimerization by binding an internal cavity of the HIF-2α PAS-B domain.

313964-19-1

C12H6ClN5O5

335.66

DMSO:12.5 mg/mL (37.24 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years