squarunkinA 是一种新型的 UNC119-货物相互作用调节剂，有效和选择性地抑制代表 Src 激酶 N 端的肉豆蔻酰化肽与 UNC119A 的结合。

squarunkinA is a novel modulator of the UNC119-Cargo Interaction, potently and selectively inhibiting the binding of a myristoylated peptide representing the N-terminus of Src kinase to UNC119A

Squarunkin A (2.5 μM, 0.625 μM, 0.078 μM, and 0.01 μM) treatment leads to a concentration-dependent reduction of Src phosphorylation.It does not target the lipoprotein-binding sites of other lipoprotein chaperones, such as PDE6d, AIPL1, and RhoGDI, which bind S-prenylated proteins.?It binds to UNC119 in cell lysate and interferes with Src activation.

2101958-02-3

C25H32F3N5O4

523.557

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