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QC6352
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
QC6352图片
CAS NO:1851373-36-8
包装与价格:
包装价格(元)
25 mg电议
50 mg电议
100 mg电议

产品介绍

产品描述

QC6352 is a selective and effective KDM4C inhibitor (IC50: 35 nM).

体外活性

QC6352 is an effective KDM4C inhibitor (IC50: 35±8 nM). QC6352 blocks the proliferation and self-renewal of BCSCs. In a concentration-dependent manner QC6352 dramatically decreases the anchorage-independent sphere-forming capacity of BCSC1 and BCSC2. The protein levels of (Epidermal growth factor receptor) EGFR are reduced in both BCSC1 and BCSC2 upon treatment with QC6352 [1][2].

体内活性

QC6352 strongly affects tumor growth and the final tumor weight of both BCSC1 and BCSC2 xenografts. QC6352 treatment is well tolerated and does not affect body weight of the mice. Treatment with the KDM4 inhibitor QC6352 blocks BCSC xenograft tumor growth[2].

Cas No.

1851373-36-8

分子式

C24H25N3O2

分子量

387.47

储存和溶解度

DMSO:25 mg/mL (64.52 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years