GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).

GNE-955 inhibits proliferation of MM.1S cells (IC50: 0.5 μM) after 72 hours treatment. GNE-955 (0.156-5 μM) inhibits the phosphorylation of BAD (s112), S6 (s235/236), S6 (s240/244) and 4EBP (s65). It shows no effect on total BAD, S6 or 4EBP protein levels.

1527523-39-2

C22H24N8O

416.48

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years