HLCL-61 hydrochloride 是小分子蛋白精氨酸甲基转移酶 5 抑制剂。

HLCL-61 hydrochloride is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.

HLCL-61 shows no inhibitory activity against the type I (PRMT1 and PRMT4) and type II (PRMT7) PRMT family members. HLCL-61 shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples.Treatment of AML cell lines (MV4-11 and THP-1) and primary blasts with HLCL-61 also results in a decrease of cell viability. HLCL-61 is also effective in promoting apoptosis in MV4-11 and THP-1 cells after 48 h[1].

CD11b expression is tested by flow cytometry on cells treated with DMSO or HLCL-61 (25 and 50 μM) for 48 h.(Only for Reference)

1158279-20-9

C23H25ClN2O

380.92

HLCL-61 HCL;HLCL61

Ethanol:15 mg/mL (32.7 mM)
DMSO:55 mg/mL (119.93 mM),warming
H2O:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years