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KDM5-C70
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
KDM5-C70图片
CAS NO:1596348-32-1
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
KDM5-C70 是 KDM5-C49 的乙酯衍生物,是一种有效的细胞渗透性泛 KDM5 组蛋白去甲基化酶抑制剂。它在骨髓瘤细胞中具有抗增殖作用,可诱导全基因组 H3K4me3 水平升高。

产品描述

KDM5-C70 is an ethyl ester derivative of KDM5-C49. KDM5-C70 is an effective, cell-permeable, and pan-KDM5 histone demethylase inhibitor. KDM5-C70 has an antiproliferative effect in myeloma cells, inducing a genome-wide elevation of H3K4me3 levels.

体外活性

KDM5-C70 (50 μM; 7 days; MM.1S myeloma cells) treatment reduces the level of phosphorylation of retinoblastoma protein (Rb) while leaving the total level of phosphorylated Rb (pRb) unchanged, indicating impairment of cell cycle progression. KDM5-C70 (1 nM-10 μM; 7 days; MM.1S myeloma cells) treatment displays antiproliferative effects after 7 days of treatment at elevated concentrations (estimated 50% reduction of viability/proliferation for KDM5-C70 at ~20 μM). Chromatin immunoprecipitation followed by next-generation sequencing displays an enhanced H3K4me3 level around transcription start sites with KDM5-C70 but little change with GSK467A at 50 μM inhibitor concentrations [1].

Cas No.

1596348-32-1

分子式

C17H28N4O3

分子量

336.43

储存和溶解度

DMSO:250 mg/mL (743.10 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years