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KDM5-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
KDM5-IN-1图片
CAS NO:1628210-26-3
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
KDM5-IN-1 是一种有效的特异性 KDM5 抑制剂,IC50 为 15.1 nM。

产品描述

KDM5-IN-1 is an effective and selective inhibitor of KDM5 with an IC50 of 15.1 nM.

体外活性

KDM5-IN-1 is significantly less potent against other KDM enzymes (1A, 2B, 3B, 4C, 5A, 6A, 7B), inhibiting KDM4C the strongest with an IC50 of 1.9 μM. KDM5-IN-1 potently inhibits KDM5B and KDM5C isoforms (IC50 of 4.7 and 65.5 nM, respectively)[1].

体内活性

KDM5-IN-1(50 mg/kg; oral) shows an unbound maximal plasma concentration Cmax>15-fold over its cell EC50 in vivo[1].

Cas No.

1628210-26-3

分子式

C17H20N6O

分子量

324.38

储存和溶解度

DMSO:30 mg/mL (92.48 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years