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BAY-598
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BAY-598图片
CAS NO:1906919-67-2
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
BAY-598 是SMYD2的选择性抑制剂,IC50值为 27 nM。

产品描述

BAY-598 is a selective inhibitor of SMYD2 with IC50 values of 27 nM.

体外活性

BAY-598 treatment blocked in vitro methylation of MAPKAPK3 by SMYD2 but had no activity against the SMYD2-related KMT SMYD3, which methylated its substrate, MAP3K2, irrespective of the presence of BAY-598.?BAY-598 treatment reduced the growth of Kras;p53 mutant PDAC cells after 9 d in culture but had little impact on the growth of Kras;p53;Smyd2 mutant cells , further supporting the specificity of this small molecule inhibitor of SMYD2 as well as a role for SMYD2 in promoting the growth of PDAC cells[1].

Cas No.

1906919-67-2

分子式

C22H20Cl2F2N6O3

分子量

525.34

储存和溶解度

DMSO:125 mg/mL (237.94 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years