SNDX-5613 是一种Menin-MLL特异性抑制剂，Ki 为 0.149 nM，IC50 为 10 在 20 nM 之间，可用于 MLL 基因重排的急性白血病研究。

SNDX-5613 is a potent and specific inhibitor of Menin-MLL(Ki of 0.149 nM and a cell based IC50 of 10-20 nM). SNDX-5613 can be used for the research of MLL-rearranged (MLL-r) acute leukemias.

SNDX-5613 treatment provides significant survival benefit and leukemic control in aggressive MOLM-13 disseminated xenografts.SNDX-5613 shows in vivo plasma( IC50 : 53 nM) .

2169919-21-3

C32H47FN6O4S

630.82

DMSO:41.67 mg/mL (66.06 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years