ZL0580 通过抑制 Tat 反式激活和转录延伸以及通过在 HIV 启动子处诱导抑制性染色质结构来诱导 HIV 抑制。

ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter.

In PBMCs of viremic HIV-infected individuals,ZL0580 (8 μM, 2 days) induces HIV transcriptional suppression with low toxicity[1]. ZL0580 treatment (10 μM) suppresses both PMA-stimulated and basal HIV transcription[1].

2377151-10-3

C25H23F3N4O4S

532.54

DMSO:250 mg/mL (469.46 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years