JQ-1 carboxylic acid 是一种细胞渗透性 BRD4 抑制剂,对 BRD4(1) 和 BRD4(2) 的 IC50 分别为 77 和 33 nM。它是一种 (+)-JQ1 衍生物,可作为合成 PROTACs 的前体。
产品描述
JQ-1 carboxylic acid is a cell-permeable BRD4 inhibitor with IC50s of 77 nM for BRD4(1) and 33 nM for BRD4(2)
体外活性
JQ-1 carboxylic acid is an inhibitor of bromodomain and extra terminal domain (BET) family proteins, blocking their interaction with acetylated histones[1],it has been used as a chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis[2][3].
Cas No.
202592-23-2
分子式
C19H17ClN4O2S
分子量
400.88
别名
JQ-1 carboxylic acid
储存和溶解度
DMSO:155 mg/mL (386.65 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years