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TTK21
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TTK21图片
CAS NO:709676-56-2
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
TTK21 是 CBP/p300 组蛋白乙酰转移酶活性的激活剂,与葡萄糖基碳纳米球结合时,可通过血脑屏障,对成人大脑神经发生和长期记忆功能有益。

产品描述

TTK21 is an activator of CBP/p300 histone acetyltransferase activity.

体内活性

a small-molecule (TTK21) activator of the histone acetyltransferases CBP/p300, which, when conjugated to glucose-based carbon nanosphere (CSP), passed the blood-brain barrier, induced no toxicity, and reached different parts of the brain.?After intraperitoneal administration in mice, CSP-TTK21 significantly acetylated histones in the hippocampus and frontal cortex.?Remarkably, CSP-TTK21 treatment promoted the formation of long and highly branched doublecortin-positive neurons in the subgranular zone of the dentate gyrus and reduced BrdU incorporation, suggesting that CBP/p300 activation favors maturation and differentiation of adult neuronal progenitors.?In addition, mRNA levels of the neuroD1 differentiation marker and BDNF, a neurotrophin required for the terminal differentiation of newly generated neurons, were both increased in the hippocampus concomitantly with an enrichment of acetylated-histone on their proximal promoter.

Cas No.

709676-56-2

分子式

C17H15ClF3NO2

分子量

357.76

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years