Alobresib 是一种BET溴结构域抑制剂，是一种抗肿瘤候选药物。

Alobresib is an inhibitor of BET bromodomain,is an antineoplastic drug candidate.

in vitro experiments demonstrated high sensitivity of USC cell lines to the exposure to GS-5829, GS-626510, and JQ1 with BET inhibitors causing a dose-dependent decrease in the phosphorylated levels of c-Myc and a dose-dependent increase in caspase activation (apoptosis).

In comparative in vivo experiments, GS-5829 and/or GS-626510 were found more effective than JQ1 at the concentrations/doses used in decreasing tumor growth in both USC-ARK1 and USC-ARK2 mouse xenograft models

1637771-14-2

C26H23N5O2

437.503

GS-5829;Vorolanib

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years