NU6140 是选择性CDK2-cyclin A抑制剂，IC50为0.41 μM。它显示出比其他 CDK 高 10 到 36 倍的选择性。它还抑制AuRORa A和AuRORa B的活性，IC50值分别为 67 和 35 nM。它还增强细胞凋亡作用并具有抗癌活性。

NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively). It also enhances the apoptotic effect and has anti-cancer activity.

NU6140 enhances catalytic activity of capase-9 and capase-3, causes an increase in the sub-G1 apoptotic cell population. NU6140 is less active on CDK1-cyclin B, CDK4-cyclin D, CDK5-p25 and CDK7-cyclin H (IC50s: 6.6, 5.5, 15 and 3.9 μM, respectively)[1].

444723-13-1

C23H30N6O2

422.52

DMSO:250 mg/mL (591.69 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years