您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > DCH36_06
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
DCH36_06
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DCH36_06图片
CAS NO:593273-05-3
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
(5E)-1-(3-chloro-4-methylphenyl)-5-[(2E)-3-(furan-2-yl)prop-2-en-1-ylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
产品介绍
DCH36_06 是一种选择性p300/CBP抑制剂,介导 p300/CBP 抑制导致白血病细胞中 H3K18 的低乙酰化,有抗肿瘤活性,对p300和CBP的IC50分别为 0.6 μM 和 3.2 μM。

产品描述

DCH36_06 as a bona fide is a potent p300/CBP inhibitor

体外活性

DCH36_06 mediated p300/CBP inhibition leading to hypoacetylation on H3K18 in leukemic cells. The suppression of p300/CBP activity retarded cell proliferation in several leukemic cell lines.In addition, DCH36_06 arrested cell cycle at G1 phase and induced apoptosis via activation of capase3, caspase9 and PARP that elucidated the molecular mechanism of its anti-proliferation activity. In transcriptome analysis, DCH36_06 altered downstream gene expression and apoptotic pathways-related genes verified by real-time PCR[1].

体内活性

DCH36_06 blocked the leukemic xenograft growth in mice supporting its potential for?in vivo?use that underlies the therapeutic potential for p300/CBP inhibitors in clinical translation[1].

Cas No.

593273-05-3

分子式

C18H13ClN2O3S

分子量

372.83

别名

(5E)-1-(3-chloro-4-methylphenyl)-5-[(2E)-3-(furan-2-yl)prop-2-en-1-ylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

储存和溶解度

DMSO:120mg/mL (321.86mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years