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EX229
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
EX229图片
CAS NO:1219739-36-2
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
EX229 是一种 AMP 活化蛋白激酶 (AMPK) 的有效变构激动剂, 是苯并咪唑衍生物,其对 α1β1γ1、α2β1γ1 和 α1β2γ1 的Kd值分别为 0.06、0.06 和 0.51 μM。

产品描述

EX229 is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively.

体外活性

Treatment of hepatocytes with EX229 (991) alone results in a slight increase in the phosphorylation of AMPK and RAPTOR only at 0.3 μM, whereas a robust increase in ACC phosphorylation is readily observed and saturated at a concentration of 0.03 μM EX229. AICAR or C13 alone robustly increases T172 phosphorylation of AMPKα, and when 991 is coincubated, there is a modest additional dose-dependent increase in AMPKα phosphorylation. RAPTOR phosphorylation is modestly increased by AICAR or C13 alone, and it is dose-dependently increased when coincubation is carried out with EX229. EX229 also dose-dependently (0.01 and 0.1 μM) inhibits lipogenesis (34% and 63%, respectively), which is further reduced when it is coincubated with a low dose of AICAR (0.03 mM) or C13 (1 μM). Treatment with EX229 promotes dose-dependent increases in ACC and RAPTOR phosphorylation. Similar to the observations in hepatocytes [2].

Cas No.

1219739-36-2

分子式

C24H18ClN3O3

分子量

431.87

储存和溶解度

DMSO:12 mg/mL (27.78 mM),Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years