ZopolreSTAT 是口服有效的醛糖还原酶抑制剂，IC50为3.1 nM。ZopolreSTAT 在糖尿病并发症方面有研究的价值。

Zopolrestat is a potent inhibitor of aldose reductase (IC50 = 3.1 nM).

Zopolrestat is a potent inhibitor of the enzymatic reduction of glyceraldehyde and glucose[1].

After the administration of Zopolrestat (2.5 mg/kg-50 mg/kg; p.o), the ED50s in reversing already elevated sorbitol accumulation in rat sciatic nerve, retina, and lens in a chronic test were 1.9, 17.6, and 18.4 mg/kg, respectively[1].

110703-94-1

C19H12F3N3O3S

419.38

Zopolrestatum;CP73850;唑泊司他;CP 73850;CP-73850

DMSO:15 mg/mL (35.77 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years