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A-9758
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
A-9758图片
CAS NO:2055271-22-0
包装:5 mg
市场价:7000元

产品介绍

产品描述

A-9758 is a RORγ ligand and a selective RORγt inverse agonist (IC50: 5 nM) and exhibits robust potency against IL-17A release. It is effective in suppressing both Th17 differentiation and Th17 effector function. A-9758 significantly attenuates IL-23 driven psoriasiform dermatitis.

体外活性

A-9758 inhibits human, mouse, dog and rat RORγ transactivation (IC50s: 38 nM, 20 nM, 25 nM and 64 nM). A-9758 displays a cofactor profile in recruiting co-repressors (NCoR1: EC50=60 nM, NCoR2: EC50=43 nM) and derecruiting co-activators (NCoA1: IC50=110 nM, PGC1α: IC50=49 nM). A-9758 inhibits TCR-mediated IL-17A secretion with an IC50 of 100 and 38 nM for human CD4+ T cells and in vitro differentiated mouse Th17 cells, respectively. A-9758 attenuates the differentiation of RORγt expressing Th17 cells and/or their effector function.

Cas No.

2055271-22-0

分子式

C25H23Cl2F3N2O3

分子量

527.36

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years