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Tebufenpyrad
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tebufenpyrad图片
CAS NO:119168-77-3
包装与价格:
包装价格(元)
25 mg电议
100 mg电议
200 mg电议

产品名称
吡螨胺
MK239
Comanche
Pyranica
产品介绍
Tebufenpyrad 是一种重要的农业化学杀螨剂,其作用类似于已知的线粒体毒物rotenone。

产品描述

Tebufenpyrad (mitochondrial complex-1 inhibitors) is an agro-chemically important acaricide that functions like the known mitochondrial toxicant rotenone.

体外活性

Exposing rat dopaminergic neuronal cells (N27 cells) to tebufenpyrad and pyridaben for 3 h induced dose-dependent cell death with an EC50 of 3.98 μM and 3.77 μM, respectively. Also, tebufenpyrad and pyridaben (3 μM) exposure induced reactive oxygen species (ROS) generation and m-aconitase damage, suggesting that the pesticide toxicity is associated with oxidative damage. Morphometric image analysis with the MitoTracker red fluorescent probe indicated that tebufenpyrad and pyridaben, as well as rotenone, caused abnormalities in mitochondrial morphology, including reduced mitochondrial length and circularity. Functional bioenergetic experiments using the Seahorse XF96 analyzer revealed that tebufenpyrad and pyridaben very rapidly suppressed the basal mitochondrial oxygen consumption rate similar to that of rotenone. Further analysis of bioenergetic curves also revealed dose-dependent decreases in ATP-linked respiration and respiratory capacity. The luminescence-based ATP measurement further confirmed that pesticide-induced mitochondrial inhibition of respiration is accompanied by the loss of cellular ATP [1].

Cas No.

119168-77-3

分子式

C18H24ClN3O

分子量

333.86

别名

吡螨胺;MK239;Comanche;Pyranica

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years