Sephin1 是一种缺乏 α2-肾上腺素能活性的 Guanabenz 衍生物，是一种磷酸酶调节亚单位PPP1R15A (R15A)的选择性抑制剂。它能够抑制 eIF2α 去磷酸化，从而延长保护反应。它具有抗朊病毒作用。

Sephin1 is a selective inhibitor of holophosphatase. Sephin1 safely and selectively inhibited a regulatory subunit of protein phosphatase 1 in vivo.

Sephin1 dose and time dependently reduced PrPSc in different neuronal cell lines which were persistently infected with various prion strains. In addition, prion seeding activity was reduced in Sephin1-treated cells. Importantly, we found that Sephin1 significantly overcame the endoplasmic reticulum (ER) stress induced in treated cells, as measured by lower expression of stress-induced aberrant prion protein[1].

In a mouse model of prion infection, intraperitoneal treatment with Sephin1 significantly prolonged survival of prion-infected mice. When combining Sephin1 with the neuroprotective drug metformin, the survival of prion-infected mice was also prolonged[1].

951441-04-6

C8H9ClN4

196.64

lcerguastat;IFB-088;Sephin 1

DMSO:200mg/ml(1017.10mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years