您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Icerguastat
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Icerguastat
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Icerguastat图片
CAS NO:951441-04-6
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
lcerguastat
IFB-088
Sephin 1
产品介绍
Sephin1 是一种缺乏 α2-肾上腺素能活性的 Guanabenz 衍生物,是一种磷酸酶调节亚单位PPP1R15A (R15A)的选择性抑制剂。它能够抑制 eIF2α 去磷酸化,从而延长保护反应。它具有抗朊病毒作用。

产品描述

Sephin1 is a selective inhibitor of holophosphatase. Sephin1 safely and selectively inhibited a regulatory subunit of protein phosphatase 1 in vivo.

体外活性

Sephin1 dose and time dependently reduced PrPSc in different neuronal cell lines which were persistently infected with various prion strains. In addition, prion seeding activity was reduced in Sephin1-treated cells. Importantly, we found that Sephin1 significantly overcame the endoplasmic reticulum (ER) stress induced in treated cells, as measured by lower expression of stress-induced aberrant prion protein[1].

体内活性

In a mouse model of prion infection, intraperitoneal treatment with Sephin1 significantly prolonged survival of prion-infected mice. When combining Sephin1 with the neuroprotective drug metformin, the survival of prion-infected mice was also prolonged[1].

Cas No.

951441-04-6

分子式

C8H9ClN4

分子量

196.64

别名

lcerguastat;IFB-088;Sephin 1

储存和溶解度

DMSO:200mg/ml(1017.10mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years