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YUM70
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
YUM70图片
CAS NO:423145-35-1
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议

产品介绍
YUM70 是一种选择性葡萄糖调节蛋白 78 抑制剂,抑制全长蛋白的 GRP78 ATPase 活性的IC50值为 1.5 μM。它在胰腺癌中诱导内质网应激介导的细胞凋亡。

产品描述

YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein). It induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer.

体外活性

YUM70, inhibited pancreatic cancer cell growth in vitro.YUM70 directly bound GRP78 and inactivated its function, resulting in ER stress-mediated apoptosis.?A YUM70 analog conjugated with BODIPY show co-localization of the compound with GRP78 in the ER.

体内活性

YUM70 in vivo efficacy in a pancreatic cancer xenograft model with no toxicity to normal tissues.YUM70 is a novel inducer of ER stress with preclinical efficacy as a monotherapy or in combination with topoisomerase and HDAC inhibitors in pancreatic cancer.

Cas No.

423145-35-1

分子式

C21H19ClN2O4

分子量

398.84

储存和溶解度

DMSO:100 mg/mL (250.73 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years