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TMS
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TMS图片
CAS NO:24144-92-1
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
(E)-2,3',4,5'-Tetramethoxystilbene
2,3',4,5'-Tetramethoxystilbene
产品介绍
TMS 是一种白藜芦醇的甲基化衍生物,也是具有选择性的CYP1B1竞争性抑制剂,其IC50=6 nM,Ki=3 nM。它对 CYP1A1 (IC50:300 nM) 及 CYP1A2 (IC50:3.1 μM) 的抑制作用较小。它具有抗癌作用。

产品描述

TMS is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1).

体外活性

Twenty-four hours after incubation with the 10 μM DOX in the presence and absence of 0.5 μM TMS, approximately 1.5 × 106 cells per six-well culture plate were collected in 100 μl lysis buffer (50 mM HEPES, 0.5 M sodium chloride, 1.5 mM magnesium chloride, 1 mM EDTA, 10% glycerol (v/v), 1% Triton X-100, and 5 μl/ml of protease inhibitor cocktail).

体内活性

Mice were administered 300 μg/kg of selective inhibitor of P450 1B1, TMS or its vehicle (dimethyl sulfoxide), i.p. every third day for the duration of the experimental period

Cas No.

24144-92-1

分子式

C18H20O4

分子量

300.354

别名

(E)-2,3',4,5'-tetramethoxystilbene;2,3',4,5'-Tetramethoxystilbene

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years