AG-636 是一种选择性可逆和具有口服活性的二氢乳清酸脱氢酶(DHODH)抑制剂，IC50 为 17 nM，具有很强的抗癌作用。

AG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects.

AG-636, in cancer cell lines of hematologic versus solid tumor origin.?Differential AG-636 activity translated to the in vivo setting, with complete tumor regression observed in a lymphoma model

AG-636 (10-100 mg/kg ;?oral gavage;?twice daily;?for 14 days) treatment results in robust tumor growth inhibition in the OCILY19 DLBCL tumor xenograft model

1623416-31-8

C21H17N3O2

343.386

DMSO:31.25 mg/mL (91.01 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years