您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Etamicastat hydrochloride
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Etamicastat hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Etamicastat hydrochloride图片
CAS NO:677773-32-9
包装与价格:
包装价格(元)
10 mg电议
50 mg电议
100 mg电议

产品名称
BIA 5-453 hydrochloride
产品介绍

产品描述

Etamicastat can be used in the research of cardiovascular diseases.Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a potent and reversible dopamine-β-hydroxylase (DBH) inhibitor with an IC50 value of 107 nM.

体外活性

Etamicastat blocks the hERG current amplitude with an IC50 value of 44 μg/mL .

体内活性

Etamicastat (50 mg/kg; a single oral administration) exhibits moderate oral bioavailability (64%), Cmax (4.9 nM), and terminal elimination half-lives (T1/2=3.7 h) in male Wistar rats.Etamicastat (100 mg/kg; administered intraperitoneally) leads to a significant reduction of noradrenaline levels in heart with concomitant increasing in dopamine levels.

Cas No.

677773-32-9

分子式

C14H16ClF2N3OS

分子量

347.81

别名

BIA 5-453 hydrochloride

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years