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Bepridil hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bepridil hydrochloride图片
CAS NO:68099-86-5
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
CERM 1978
盐酸苄普地尔
产品介绍
Bepridil hydrochloride 是一种钙通道阻滞剂,还抑制 Na+/Ca2+ 交换 (NCX)、钠通道和心脏肌膜 KATP 通道,具有抗心绞痛的作用。

产品描述

Bepridil is a calcium channel blocker and also inhibits Na+/Ca2+ exchange (NCX), sodium channels and cardiac sarcolemmal KATP channels.

体外活性

Bepridil (1-100 microM) inhibited the K(ATP) channel current in a concentration-dependent manner. The IC(50) value of bepridil was estimated to be 10.5 microM for outward K(ATP) channel currents (holding potential, +60 mV) and 6.6 microM for inward K(ATP) channel currents (holding potential, -60 mV). Bepridil (0.1-30 microM) also inhibited K(Na) channel currents measured at the holding potential of -60 mV, in a concentration-dependent manner with an IC(50) value of 2.2 microM [2].

体内活性

The predominant effects of Bepridil (cumulative dose = 9.0 mg/kg i.v.) in the conscious rat were reduced coronary vascular resistance and heart rate. Bepridil showed selectivity for the coronary circulation since systemic vascular resistance was not significantly reduced until cumulative i.v. dosage of 21.0 mg/kg was administered [1].

Cas No.

68099-86-5

分子式

C24H35ClN2O

分子量

403.01

别名

CERM 1978;盐酸苄普地尔

储存和溶解度

DMSO:130 mg/mL (322.58 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years