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WNK-IN-11
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
WNK-IN-11图片
CAS NO:2123489-30-3
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Allosteric WNK Kinase Inhibitor
产品介绍
Allosteric WNK Kinase Inhibitor 是(WNK)激酶的变构抑制剂,能够抑制 WNK1 (IC50:4 nM) 。

产品描述

WNK-IN-11 is an allosteric With-No-Lysine (WNK) kinase inhibitor,WNK1(IC50 : 4 nM)

体外活性

WNK-IN-11 (compound 11) shows IC50<2 μM in the cellular OSR1 phosphorylation assay with reasonable aqueous solubility, albeit with still rather high microsomal clearance. WNK-IN-11 shows ATP noncompetitive inhibition. When tested against a panel of 440 human kinases at 10 μM concentration, 2500-fold above enzyme IC50 value, WNK-IN-11 shows excellent selectivity with only a few significant off-target kinase inhibitions, most notably BTK and feline encephalitis virus-related (FER) kinase, neither of which are implicated for blood pressure regulation. This excellent selectivity profile is consistent with the predicted allosteric binding mode outside the highly conserved ATP-pocket.

Cas No.

2123489-30-3

分子式

C21H21Cl2N5OS

分子量

462.39

别名

Allosteric WNK Kinase Inhibitor

储存和溶解度

DMSO:150 mg/mL (324.39 mM)
H2O:Insoluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years