产品描述
TAS4464 is a highly potent and selective inhibitor of the NEDD8 activating enzyme (IC50: 0.955 nM).
体外活性
TAS4464 treatment inhibits cullin neddylation. TAS4464 induces the accumulation of CRL substrates such as CDT1, p27, and phosphorylates IκBα in 47 human cancer cell lines.
Cas No.
1848959-10-3
分子式
C21H23FN6O6S
分子量
506.51
储存和溶解度
DMSO:125 mg/mL (246.79 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years