MG-115是一种有效的、可逆的蛋白酶体抑制剂。MG-115对20S和26S蛋白酶体的Kis分别为21nM和35nM。

MG-115 is a potent, reversible proteasome inhibitor. MG-115 shows Kis of 21 nM and 35 nM for 20S and 26S proteasome, respectively.

Treatment of HepG2 cells for 24 h with MG-115 resulted in a dose-dependent decrease in cell viability measured by the MTT. The LD50 was approximately 2 mM for MG-115[3].

133407-86-0

C25H39N3O5

461.59

Z-LL-Nva-CHO

DMSO:45mg/mL (97.5mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years