LY-2584702 tosylate 是一种选择性的 ATP 竞争性 p70S6K 抑制剂，IC50为 4 nM，对S6K1的IC50为 2 nM，用于研究癌症治疗的试验。

LY2584702 Tosylate is a selective, ATP-competitive p70S6K inhibitor, used in trials studying the treatment of cancer.

In HCT116 colon cancer cells, LY2584702 inhibits phosphorylation of the S6 ribosomal protein (pS6) with IC50 of 0.1-0.24 μM. [1] LY2584702 has significant synergistic effects when combined with EGFR inhibitor erlotinib or with the mTOR inhibitor everolimus. [2]

LY2584702 (12.5 mg/kg BID), demonstrates significant antitumor efficacy in both U87 mg glioblastoma and HCT116 colon carcinoma xenograft models. [1]

1082949-68-5

C28H27F4N7O3S

617.62

LY2584702 tosylate

Ethanol:<1 mgml
DMSO:7 mg/mL(11.3 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years