EPAC 5376753 是 EPAC1 的变构抑制剂，在瑞士 3T3 细胞中的 IC50 为 4 μM。

EPAC 5376753 is an allosteric inhibitor of EPAC1 with an IC50 of 4 μM in Swiss 3T3 cells.

EPAC 5376753 decreases the conformational changes of EPAC necessary for its activation. EPAC 5376753 inhibits EPAC signaling in cells and EPAC-mediated migration in fibroblasts[1].

302826-61-5

C15H8Cl2N2O3S

367.21

5-{[5-(2,4-dichlorophenyl)furan-2-yl]methylidene}-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years