MRTX1133 是一种有效的、选择性的、非共价的 KRasG12D 抑制剂。它在含有 KRasG12D 突变的肿瘤模型中具有显着的体内功效。

MRTX1133 is a potent, selective, noncovalent KRASG12D inhibitor. It has picomolar binding affinity, single-digit nanomolar activity in cellular assays. In addition, it has significant in vivo efficacy in tumor models harboring KRASG12D mutations.

2621928-55-8

C33H31F3N6O2

600.63

DMSO:230 mg/ml (382.93 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years