APS6-45 是一种可口服的肿瘤校准抑制剂，可抑制 Ras/MAPK 信号传导并表现出抗肿瘤活性。

APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.

APS6-45 (1 μM; 1 h) strongly inhibits RAS pathway activity signaling in human MTC cell lines TT and MZ-CRC-1[1].

APS6-45 did not affect body weight of dosed(10 mg/kg) mice after 30 d.APS6-45 (0.1-160 mg/kg; a single p.o.) does not cause detectable toxic effects in mice[1].

2188236-41-9

C23H16F8N4O3

548.393

DMSO:240mg/mL (437.67mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years