BI-2852 是具有纳摩尔亲和力的开关 I/II 口袋（SI/II-口袋）的 KRas 抑制剂，可抑制 KRas 突变细胞的下游信号传导和抗增殖作用。

BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) with nanomolar affinity. BI-2852 is leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.

BI-2852 (Compound 1; 10 nM-10 μM; 2 hours) shows a dose-dependent pERK modulation and antiproliferative effect at EC50s of 6.7 μM and 5.8 μM in low serum and soft agar conditions in NCI-H358 cells.

2375482-51-0

C31H28N6O2

516.59

DMSO:55 mg/mL (106.47 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years