K-Ras(G12C) inhibitor 9 是致癌 K-Ras(G12C) 的变构抑制剂。
产品描述
K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).
体外活性
K-Ras(G12C) inhibitor 9 belongs to a series of small molecules, which irreversibly bind to a common oncogenic mutant K-Ras(G12C) and blocks K-Ras(G12C) interactions. Some of them decrease viability and increase apoptosis of G12C-containing cancer cell lines. [1]
Cas No.
1469337-91-4
分子式
C16H21ClIN3O4S
分子量
513.78
储存和溶解度
Ethanol:<1 mgml
H2O:<1 mgml
DMSO:53 mg/mL (103.15 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years