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MAP4K4-IN-3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MAP4K4-IN-3图片
CAS NO:1811510-58-3
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Compound 17
产品介绍
MAP4K4-IN-3 是MAP4K4选择性抑制剂,在激酶实验中IC50为 14.9 nM,在细胞实验中IC50为 470 nM。具有抗糖尿病作用。

产品描述

MAP4K4-IN-3 may be a viable target for antidiabetic agents, a serine/threonine protein kinase.

体外活性

MAP4K4-IN-3, Antidiabetic agent.MAP4K4-IN-3 is a potent and selective MAP4K4 inhibitor with an IC50 of 14.9 nM in kinase assay, an IC50 of 470 nM in cell assay.

体内活性

Oral dosing in telemetered rats for 5 days with MAP4K4-IN-3 (Compound 2;?25 mg/kg, b.i.d.) results in a number of adverse effects.For cardiovascular end points, maximal heart rate increases of 25 bpm, relative to controls, are induced by treatment with MAP4K4-IN-3[2].?Substantial weight losses (7%) and body temperature increases (0.4°C) relative to controls are observed over the course of the study.?

Cas No.

1811510-58-3

分子式

C15H12ClN5

分子量

297.74

别名

Compound 17

储存和溶解度

DMSO:8 mg/mL (26.87mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years