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ZCL-278
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ZCL-278图片
CAS NO:587841-73-4
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
ZCL278, ZCL 278
产品介绍

生物活性

ZCL-278是Cdc42的选择性抑制剂。以Cdc42鸟嘌呤核苷酸交换因子交叉蛋白(ITSN)的结合位点为目标。抑制Cdc42介导的细胞效应,包括3T3成纤维细胞中微峰的形成和初生新生皮质神经元中的神经元分支。还抑制PC3细胞的细胞运动和迁移,无细胞毒性作用。

靶点信息

Cdc42 GTPase
11.4 μM(Kd)

化学数据

目录号A13403
作用机制Inhibitor (抑制剂)
M. Wt584.89
FormulaC21H19BrClN5O4S2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.587841-73-4
SynonymsZCL278, ZCL 278
SMILESCC1=CC(=NC(=N1)NS(=O)(=O)C2=CC=C(C=C2)NC(=S)NC(=O)COC3=C(C=C(C=C3)Br)Cl)C

溶解度

In vitroDMSO99 mg/mL (169.26 mM)
WaterInsoluble
EthanolInsoluble
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM17.1 mL85.49 mL170.97 mL
0.5 mM3.42 mL17.1 mL34.19 mL
1 mM1.71 mL8.55 mL17.1 mL
5 mM0.34 mL1.71 mL3.42 mL

*The above data is based on the productmolecular weight 584.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.