Proparacaine hydrochloride 是 LIDOcaine的衍生物,具有糖皮质激素样活性和免疫调节作用。
产品描述
Proparacaine Hydrochloride is the hydrochloride salt form of proparacaine, a benzoic acid derivative with local anesthetic property. Proparacaine hydrochloride stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting sodium ion influx required for the initiation and conduction of impulses within the neuronal cell, and resulting in a loss of sensation.
体外活性
Proparacaine is more potent and less toxic than cocaine. [1] Proparacaine significantly increases in FHV-1 (P< 0.01), C. felis, and 28S rDNA Ct values when fusidic acid is used. [2]
体内活性
Proparacaine inhibits corneal epithelial migration and adhesion through alteration of the actin cytoskeleton. [3] Proparacaine acts like bupivacaine or lidocaine and produces dose-related spinal blockades of motor function, proprioception and nociception. Intrathecal proxymetacaine also produces longer sensory blockade than motor blockade. [4]
Cas No.
5875-06-9
分子式
C16H26N2O3·HCl
分子量
330.86
别名
Proparacaine HCl;Proxymetacaine Hydrochloride;盐酸丙美卡因
储存和溶解度
H2O:61 mg/mL (184.4 mM)
DMSO:10 mg/mL (30.2 mM)
Ethanol:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years