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Ropivacaine hydrochloride monohydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ropivacaine hydrochloride monohydrate图片
CAS NO:132112-35-7
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Ropivacaine HCl monohydrate
盐酸罗哌卡因
盐酸罗哌卡因一水合物
LEA 103
Ropivacaine HCl
LEA-103 HCl
产品介绍
Ropivacaine HCl monohydrate 是钠通道阻断剂,通过可逆地抑制钠离子内流从而引起神经纤维脉冲传导阻滞。Ropivacaine HCl monohydrate 也是 K2P(双孔钾通道)TREK-1的抑制剂。在动物实验模型中,Ropivacaine HCl monohydrate可用于神经性疼痛的缓解。

产品描述

Ropivacaine HCl is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.

体外活性

Raltitrexed induces double-stranded DNA breaks in a concentration-dependent manner. In Lovo cells and LS174T cell lines containing wild-type p53, Raltitrexed increases the levels of the Bax protein up to 5-fold. In human colon cancer cells, Raltitrexed is actively absorbed into cells and is then rapidly and extensively metabolized into a series of polyglutamates, which results in the effective inhibition of thymidylate synthase. Raltitrexed is delivered to the brain very quickly and can be detected in all brain tissues within 5 minutes. In human colon cancer cells, the combination of Raltitrexed and SN-38 results in a synergistic cytotoxic effect within a range of concentrations. Raltitrexed is a specific folate-based inhibitor of thymidylate synthase. The effect on the activity of advanced rectal cancer is similar to fluorouracil (5-fluorouracil) plus leucovorin. Raltitrexed produces activity by rapid cell entry and glutamination. The glutaminated derivatives are more than 100 times more active than the parent compound. In the HCT-8 cell line, Raltitrexed results in an increase in intracellular phosphoribosyl pyrophosphate (PRPD) indicating that the cytotoxic effect of Raltitrexed in combination with 5-FU is due to increased nucleotide formation of 5-FU. Combinations of Raltitrexed and folinic acid (5FU-FA) show a combination of mode-dependent, synergistic inhibition of proliferation, which is determined by measuring the combination series. Raltitrexed combined with Vorinostat produced significant synergistic effects of cell cycle perturbation and S-phase arrest.

Cas No.

132112-35-7

分子式

C17H29ClN2O2

分子量

328.88

别名

Ropivacaine HCl monohydrate;盐酸罗哌卡因;盐酸罗哌卡因一水合物;LEA 103;Ropivacaine HCl;LEA-103 HCl

储存和溶解度

Ethanol:<1 mgml
DMSO:62 mg/mL (199.44 mM)
H2O:46 mg/mL (147.97 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years