Tenapanor是钠氢离子交换NHE3的有效抑制剂, 对人和大鼠NHE3的IC50分别是5和10 nM。

Tenapanor is an inhibitor of the sodium-proton (Na(+)/H(+)) exchanger NHE3, which plays a prominent role in sodium handling in the gastrointestinal tract and kidney. Tenapanor possesses an excellent preclinical safety profile and, as of now, there are no serious concerns about its side effects.

1234423-95-0

C50H66Cl4N8O10S2

1145.05

RDX-5791;AZD 1722;RDX 5791;AZD-1722;RDX5791;Tenapanor free base;AZD1722

DMSO:50 mg/mL (43.67 mM),Need ultrasonic
DMSO:Soluble
H2O:< 0.1 mg/mL (insoluble)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years