PF-05089771是具有口服有效的、选择性的Nav1.7丙烯酰胺抑制剂。PF-05089771在疼痛和糖尿病神经性疾病的研究中具有价值。

PF-05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV. It shows a slow onset of the block that is depolarization and concentration-dependent.

1235403-62-9

C18H12Cl2FN5O3S2

500.35

PF05089771;PF-05089771

DMSO:30 mg/mL (59.96 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years