Myomodulin acetate(110570-93-9 free base) 存在于两个已识别的海兔神经元中,它们包含肌调节蛋白 A、ARC 运动神经元 B16 和腹部神经元 L10。
产品描述
Myomodulin acetate is present in two identified aplysia neurons that contain myomodulin A the ARC motor neuron B16 and the abdominal neuron L10.
体外活性
Myomodulin decreases period and increases spike frequency in oscillator heart interneurons. Myomodulin enhances the hyperpolarization-activated cation current and inhibits the electrogenic Na/K pump[1]. A myomodulin peptide has been suggested to mediate the response of the giant glial cells to stimulation of the Leydig interneuron in the central nervous system of the leech Hirudo medicinalis. The peptide evokes a membrane outward current (EC50 approximately 2 μM), which neither desensitizes nor shows any sign of run-down, and elicits a K+ conductance increase of the glial cell membrane[3]. Myomodulin modulate ion channels in a wide variety of organisms including Aplysia, Lymnaea, and Pleurobranchaea. Myomodulin differentially modulates the potassium currents and reduces the amplitude of the Ca2+ current by 20%[2].
Cas No.
TP1852L
分子式
C38H71N11O10S2
分子量
906.17
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years