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Levcromakalim
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Levcromakalim图片
CAS NO:94535-50-9
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
左色满卡林
BRL 38227
(-)-Cromakalim
产品介绍
Levcromakalim 是 一种ATP 敏感性的 K+通道 (KATP) 激活剂。

产品描述

Levcromakalim is an activator of the ATP-sensitive K+ channel.

体外活性

Levcromakalim inhibits spontaneous contractions completely in a glibenclamide-sensitive manner. LevCromakalim (5 μM) inhibits spontaneous contractions, which are recovered by glibenclamide. Levcromakalim (1, 5 and 10 μM) inhibits phasic contractions to 34±21.1%, 20.1±20.0% and 0% of the control. Glibenclamide reverses the inhibition of spontaneous isometric contractions caused by LevCromakalim (5 μM) to 84±1.5% of the control. Levcromakalim (20 and 100 μM) also inhibits oxytocin (OXT) (10 nM)-induced phasic contractions to 34±21.4% and 14±12.6% of the control [2]. LevCromakalim induces dose-dependent relaxation in both the young and old mesenteric artery (MAs); there is no difference in relaxation with age. However, the relaxation is markedly reduced in response to the high-salt (HS) diet in the old MAs (P<0.05). Maximum dilations to Levcromakalim (10-4 M) are 97 ± 3% in the young MAs versus 98 ± 1% in the young salt arteries, while dilations are 99±0.7% in the old MAs when compared with 85 ± 5% in the old salt arteries (P<0.05) [3].

Cas No.

94535-50-9

分子式

C16H18N2O3

分子量

286.33

别名

左色满卡林;BRL 38227;(-)-Cromakalim

储存和溶解度

H2O:Insoluble
DMSO:50 mg/mL (174.62 mM )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years